Irvingia is derived from a West African bush or wild mango tree. The trees produce eatable fruits, and its dika nuts are well-known. Irvingia contains a high percentage of fat (50%) like other nuts and seeds, and oil may be produced from them. Irvingia also has 14% fibre in it. Along with their many health advantages, dietary fibres are frequently advised for their ability to aid in weight loss.
In order to determine if Irvingia gabonensis may aid in weight reduction, a research team from Cameroon (Western Africa) set up a randomised double blind trial in 2005. This was done because of the plant's traditional use in African cuisine and its reputation as a healthy meal. 40 obese participants were split into experimental and placebo groups. 1.0 gramme was given to the test group.
The measurements of the subjects' hips, waists, and body weight were taken each week during examinations. After an overnight fast, blood samples were taken, assessed for blood pressure, and analysed for glucose, triacylglycerol, HDL cholesterol, and total cholesterol. During the study, the individuals were asked questions regarding their exercise habits and dietary habits. They were also given instructions to follow a low-fat diet consisting of 1800 calories per day and to keep a seven-day food diary.
The Irvingia group had dropped an average of 5.26 kilogrammes (11.5 lbs) by the conclusion of the 30-day experiment, whereas the placebo group had only lost 1.32 kilos (2.9 lbs). Systolic blood pressure, total cholesterol, triglycerides, and LDL cholesterol all fell in the Irvingia-treated group. The HDL cholesterol level rose.
This was the first study to demonstrate that Irvingia could aid in weight reduction. The Irvingia group lost more weight for what reason? It's unclear, but in studies of free-living people, greater weight loss frequently indicates that the experimental group consumed less calories, rather than necessarily as a result of a direct impact on physiology, hormones, or metabolism.
The findings of the same research team's second study on Irvingia and weight reduction were released in March 2008. This time, Irvingia was coupled with the succulent vine Cissus quadrangularis, which is indigenous to Southeast Asia and West Africa. 72 participants were split into three groups: placebo, Cissus extract alone (150 mg twice day), and Cissus-Irvingia combined (250 mg twice daily).
The exact same tests and measures as in the 2005 research were performed. Total cholesterol, LDL cholesterol, and fasting blood sugar all improved after 10 weeks. The cissus group dropped 8.82 kg (19.4 lbs), the Cissus-Irvingia group lost 11.86 kg (26.1 lbs), and the placebo group lost 2.1 kg (4.6 lbs).
The researchers (Oben and Ngondi) believed there was something more going on because it is extremely improbable, if not impossible, to attribute 26 pounds lost in 10 weeks simply to a fibre supplement. They claimed that Irvingia gabonensis could influence body weight in obese people through PPAR gamma, leptin, adiponectin, or glycerol-3 phosphate dehydrogenase, among other possible methods.
To explore these possibilities, they designed a second 10-week randomised double-blind placebo-controlled research. Two groups of 120 participants each got 150 mg of Irvingia gabonensis extract twice daily. The other group received a placebo.
Once more, the levels of total and LDL cholesterol decreased greater in the Irvingia group than in the placebo group (27% vs. 4.8%). Compared to the placebo group, the Irvingia gabonensis group saw a 6.3% drop in body fat. In the Irvingia gabonensis group, weight reduced by 12.8 kg (28.1 pounds), compared to 0.7 kg (1.5 pounds) in the placebo group.
Adiponectin, a protein generated by fat cells that increases insulin sensitivity, and leptin, an anti-starvation hormone that alerts the body and brain to the presence of fat storage, were also shown to have positive alterations.
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